dbSNP rs#p値染色体上（症例全体）Position1263939470.000000607rs7771758239709010.000001732kgp81134332128485790.0000046651:21302192139891880.000005012rs46322261302513610.0000059879:1330136401348469220.000007522rs12622574854233920.00001002kgp121249751753650910.00001577rs755431252229043700.0000159rs1104668630662990.00001668kgp15142390797472270.000016976:8045694439678520.00001703rs797479062128122500.000018911:212985592-GA1554234850.00002099JHU_6.155744618812038250.00002252JHU_7.808331401334440700.00002261JHU_3.1331629131199121260.00002351rs76331529234522250.0000240518:34522221211579250.00002637kgp8398245445153010.000026496:4448303849850850.000029479:49850851334446470.00003135rs75469112404634700.000032578:403209891676335720.000035193:1673513601334622260.00003531rs9873492122006460.0000385819:1231146172044300.000038926:7204663606043300.00003931rs724025404584200.000039328:40315939404698480.000039328:40327367404704730.000039328:40327992396304840.00004118rs1173414591138503470.00004148kgp211074801673911580.00004173JHU_6.1678046451554240530.00004255kgp2539176751633720.00004381rs7441421429861250.00004619rs73717915113781940.00005007rs11948339JHU_3.19168568191270770.00005109JHU_11.1345787321347088390.000059081613112530.00006684rs145778277561958790.0000766612:56589663rs7805035259262700.000080511360035050.000082842:136761075180457400.00008413kgp156304681344294100.00008589rs64135171254098330.00008854rs10934713rs188596314400883820.00008997853435670.00009021rs17796783kgp141555322338599610.00009207遺伝子名3.741TATDN33.71NOX33.7563.753LOC100289333RREB13.672CTNND23.749表2 オピオイド投与量の表現型に対するDominant model（Dom）によるゲノムワイド関連解析結果の上位候補遺伝子多型ランク染色体番号10Dom118Dom11Dom318Dom4Dom592Dom64Dom71Dom812Dom9Dom1016Dom1118Dom121Dom13Dom1467Dom153Dom1610Dom1718Dom18Dom1886Dom209Dom213Dom228Dom23Dom2433Dom2519Dom266Dom273Dom28Dom2988Dom308Dom303Dom30Dom3346Dom346Dom3518Dom358Dom37Dom3853Dom3911Dom40Dom40512Dom42Dom4372Dom441Dom449Dom463Dom47Dom482114Dom49Dom502全解析結果中上位候補50遺伝子多型についての結果のみ提示。§: mm、マイナーアレルホモ接合; Mm、ヘテロ接合; MM、メジャーアレルホモ接合。 NA、Not Availabe。遺伝子型分布§mm/Mm/MM0/24/4012/47/3761/14/4091/27/3960/2/42310/95/3201/67/3560/3/4224/74/3467/116/3020/4/4212/49/3741/12/4032/44/3765/113/2984/80/3410/3/4220/2/4215/110/3100/7/4181/52/3684/79/3410/4/4201/7/4167/81/3371/9/4140/5/420表現型平均値（mg/日）§mmMmMMNA4.8363.7214.0884.4843.694DLGAP1,DLGAP1-AS46.1964.942.6914.7433.718DLGAP1,DLGAP1-AS4NA7.1883.7674.8874.1143.651ACMSD1.5584.3513.688NA6.4353.765TNR3.4424.3023.6823.8774.1483.641LINC00982NA6.0683.7624.0884.3993.701DLGAP1,DLGAP1-AS46.1964.8883.724.6534.413.633.3884.2683.675BFSP2NA6.3813.765SEC23IPNA6.9723.773TGIF13.5213.4223.916NA5.4663.7554.2634.3643.7043.3884.2673.681BFSP2NA5.976.3995.1783.752WDR493.9284.2273.674BFSP25.9695.07NA5.7383.763.9564.1253.643FHIT3.763NA5.973.763NA5.97NA5.973.763NA5.9643.7634.1114.5563.7244.3153.9743.6044.6534.3733.709NOX33.5073.4433.915NA5.5483.758LOC1001336693.5354.233.9084.2643.688NA4.9563.747NA4.9483.747GABRB2NA4.6973.746NA4.4273.719NA4.5693.731DARS-AS1NA4.984.5284.2083.692RXRA4.6134.1763.685NA5.8683.764DSCAM4.2234.2633.6974.7384.6923.7384.1683.65414/115/2960/4/4210/4/4210/4/4210/4/4211/30/39333/151/2362/45/37812/112/2990/6/4197/87/3314/69/3520/13/4120/13/4120/21/3910/39/3860/27/3970/12/4136/66/3535/76/3440/4/4212/63/3602/18/405136
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