表現型平均値（mg/日）§mmMmMM6.0554.0143.688ANGPT16.0553.9893.693ANGPT13.1573.8213.9065.5423.7493.7564.8293.6483.776PCDH97.043.8263.766.0733.6033.7924.3623.6873.71APOBEC14.3423.7563.6365.1293.7553.7455.4793.7423.758TNR5.4793.7423.761TNR4.3533.683.7255.0043.6483.7864.343.7283.675.7663.9323.7234.6223.8053.6734.3163.6543.7594.3163.6543.7594.6023.7233.732MYRFL4.5233.6473.781SCN5A4.7833.8723.664.3873.7113.716.8353.9093.7553.4063.9773.802DGKB4.2943.6563.7496.8223.6893.7764.4223.6573.767UBASH3B遺伝子型分布§mm/Mm/MM5/88/3325/90/33051/162/2127/106/31219/131/2752/53/3704/67/35455/197/17359/192/17011/104/3107/82/3367/82/33554/201/17013/123/28956/185/1845/75/34526/169/23059/213/15359/213/15327/166/23232/170/22318/152/25546/193/1862/39/38499/185/14060/212/1522/38/38441/180/204112/189/1243.4353.9983.772DGKB60/212/15360/212/15360/212/1532/66/35777/222/12631/155/23931/152/24256/183/1863/89/33111/95/3198/100/3178/100/3175/81/3398/95/32022/162/24122/162/24110/103/31287/204/13436/163/22340/168/21769/219/1374.2943.6563.7594.2943.6563.7594.2943.6563.7593.9423.737MCHR26.794.2223.7423.589PTPRA3.8593.83COL6A63.053.053.8493.836COL6A64.3123.6743.732HHIPL16.2183.8413.746GABBR25.0353.4623.8363.775.2563.715.2563.713.775.6533.8233.747RBFOX15.2563.6883.7783.751GRIP12.9153.952.9153.953.751GRIP15.0913.7573.75NALCN4.1823.6283.7624.4453.7593.69C2orf913.1583.8533.8454.2413.6723.732STOX2p値遺伝子名RYR2表3 オピオイド投与量の表現型に対するRecessive model（Rec）によるゲノムワイド関連解析結果の上位候補遺伝子多型ランク染色体染色体上番号（症例全体）Position8Rec11074214590.0000015848Rec11074601000.0000015843Rec31834338720.00000760710Rec41140174650.00001102Rec513666528390.000012549GSA-rs727527011259922740.00001526Rec690751970.000016291Rec776568310.0000164712Rec82394308200.000017582Rec9Rec1021341594340.000022781754095580.000022841Rec111754127900.000023511Rec121880227360.000027084Rec13Rec148918613900.0000285349816020.000028899Rec151089794390.000029958Rec161245049450.000036267Rec17538128160.0000375217Rec18Rec1817538131540.00003752699383130.0000387612Rec20386159890.000046543Rec21828611170.000050414Rec222376101270.000050531Rec23Rec2411182703770.00005196141590180.000054697Rec25538061490.0000556917Rec261227549060.000056226Rec271226785060.0000580111Rec28Rec297141678350.00005852538015330.0000648217Rec30538028120.0000648217Rec30538074330.0000648217Rec30Rec336999801790.0000671829241220.0000701320Rec341306456790.000072393Rec351306494570.000072393Rec35996481010.0000725314Rec37Rec389GSA-rs73488500985429750.00007657279228270.0000836918Rec39932058280.0000845Rec405Rec40932318330.00008467858560.0000842416Rec42Rec435932359570.00008758666733270.0000911512Rec44666752230.0000911512Rec441012494870.0000913413Rec46817608180.00009865Rec47Rec482419393130.00009953249510060.00010253Rec49Rec5041839186760.0001026全解析結果中上位候補50遺伝子多型についての結果のみ提示。§: mm、マイナーアレルホモ接合; Mm、ヘテロ接合; MM、メジャーアレルホモ接合。dbSNP rs#rs1283671rs1283720rs10937129rs10749151rs9529111rs117964643kgp2401165kgp12247990rs11692586rs12119177rs859468rs2131287rs4734909rs10758669rs4620259rs763434rs9896204rs9896751rs789559kgp8286424rs8019184kgp63935551:118813000rs12538534rs12453607kgp3351958rs7117189kgp11942343rs7221455rs4594287rs4271635rs17059990kgp10722247rs1022033rs7636656rs12890020rs7232372rs11747478rs4869419rs74007038rs12657207rs10878494rs7310442rs7982539rs47038422:42166453rs41396146rs2309942137
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